What are the different types of HPLC vials?

High-Performance Liquid Chromatography (HPLC) vials come in various types and configurations to suit different analytical needs. The choice of HPLC vials depends on factors such as sample type, analysis requirements, and instrument compatibility. Here are some common types of HPLC vials:

  1. Screw-Thread Vials:
    • Standard Opening (8-425, 9-425, 10-425): These vials have a standard 8-425, 9-425, or 10-425 neck finish and are sealed with a screw cap.
    • Wide-Mouth Opening (10-425, 13-425, 15-425): These vials have a wider opening for easy sample loading and are compatible with a variety of autosamplers.
  2. Snap Cap Vials:
    • These vials have a snap cap instead of a screw cap, making them easy to open and close. They are suitable for applications where frequent access to the vial is required.
  3. Crimp-Top Vials:
    • These vials are sealed with a metal crimp cap. They are often used for applications where a secure seal is required.
  4. Shell Vials:
    • Shell vials consist of a cylindrical glass “shell” with a crimp or screw neck. They are available with various inserts for sample containment.
  5. Headspace Vials:
    • Designed for analysis of gas in the headspace of a sample, these vials typically have a rounded or flat bottom and are sealed with a septum cap.
  6. Micro vials:
    • Smaller vials are designed for use with limited sample volumes. They are available in various configurations, such as screw-thread or snap cap.
  7. Specialty Vials:
    • Vials are designed for specific applications, such as LC-MS analysis, low-volume sampling, or storage. They may have unique features to enhance performance in specialized environments.
  8. Pre-Slit Septa Vials:
    • Vials with pre-slit septa, can save time during sample preparation as they eliminate the need for manual septum piercing.
  9. Polymer Vials:
    • Vials are made from polymers such as polypropylene or cyclic olefin copolymer (COC). These may be preferred for certain applications due to their inertness and compatibility.

When selecting HPLC vials, it’s crucial to consider factors like the sample matrix, required sample volume, compatibility with the HPLC instrument, and the nature of the analysis being performed. Always follow the manufacturer’s recommendations and guidelines for your specific instrument and application.

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